Enables iron ion binding activity. Involved in septate junction assembly. Located in endosome; plasma membrane; and septate junction. Is expressed in several structures, including adult brain; adult head; clypeo-labral primordium; epithelium; and gut section. Used to study chromosome 3q29 microdeletion syndrome. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); atransferrinemia; carcinoma (multiple); glucose metabolism disease (multiple); and restless legs syndrome. Orthologous to several human genes including MELTF (melanotransferrin) and TF (transferrin).
FB Description
Transferrin 2 (Tsf2) encodes a protein that requires binding with iron for protein function. It is localised at the paracellular septate junctions in epithelial tissues and is required for junction assembly. Tsf2 mutants show overelongated tracheal tubes.