Gene

Tsf2

Species
Drosophila melanogaster
Symbol
Tsf2
Name
Transferrin 2
Synonyms
  • CG10620
  • Melanotransferrin
Biotype
protein coding gene
Automated Description
Enables iron ion binding activity. Involved in septate junction assembly. Located in endosome; plasma membrane; and septate junction. Is expressed in several structures, including adult brain; adult head; clypeo-labral primordium; epithelium; and gut section. Used to study chromosome 3q29 microdeletion syndrome. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); atransferrinemia; carcinoma (multiple); glucose metabolism disease (multiple); and restless legs syndrome. Orthologous to several human genes including MELTF (melanotransferrin) and TF (transferrin).
FB Description
Transferrin 2 (Tsf2) encodes a protein that requires binding with iron for protein function. It is localised at the paracellular septate junctions in epithelial tissues and is required for junction assembly. Tsf2 mutants show overelongated tracheal tubes.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11485
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
12.5305M12.5310M12.5315M12.5320M12.5325M12.5330M12.5335M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions