Enables microtubule binding activity. Involved in several processes, including microtubule cytoskeleton organization; negative regulation of microtubule depolymerization; and non-motile cilium assembly. Located in ciliary transition zone and microtubule organizing center. Is expressed in embryonic brain; larval ventral nerve cord; organism; and spermatozoon. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 8 and spermatogenic failure 26. Orthologous to several human genes including CEP135 (centrosomal protein 135).
FB Description
Centrosomal protein 135kDa (Cep135) encodes a microtubule binding protein important for centriole elongation and stability. It promotes centrosome asymmetry and spindle orientation in neuroblasts and it is required for male fertility.