Gene

Cep135

Species
Drosophila melanogaster
Symbol
Cep135
Name
Centrosomal protein 135kDa
Synonyms
  • Bld-10
  • Bld10
Biotype
protein coding gene
Automated Description
Enables microtubule binding activity. Involved in several processes, including microtubule cytoskeleton organization; negative regulation of microtubule depolymerization; and non-motile cilium assembly. Located in ciliary transition zone and microtubule organizing center. Is expressed in embryonic brain; larval ventral nerve cord; organism; and spermatozoon. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 8 and spermatogenic failure 26. Orthologous to several human genes including CEP135 (centrosomal protein 135).
FB Description
Centrosomal protein 135kDa (Cep135) encodes a microtubule binding protein important for centriole elongation and stability. It promotes centrosome asymmetry and spindle orientation in neuroblasts and it is required for male fertility.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23159
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
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15.117M15.118M15.119M15.120M15.121M15.122M15.123M15.124M15.125M15.126M15.127M15.128M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions