Gene

Mes2

Species
Drosophila melanogaster
Symbol
Mes2
Name
Mesoderm-expressed 2
Synonyms
  • adfR
  • CG11100
Biotype
protein coding gene
Automated Description
Involved in ecdysis, chitin-based cuticle and instar larval development. Located in nucleus. Is expressed in several structures, including endoderm anlage; glial cell; head epidermis primordium; pericardial cell; and somatic trunk mesoderm derivative.
FB Description
Mesoderm-expressed 2 (Mes2) encodes a transcription regulator involved in ecdysis.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12243
Stringency:
Additional filters to further constrain the results:
No ortholog matching your filter. Please try a less stringent filter.
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
CG12768146441283 of 8  
brwl241435202 of 8  
CG7745339333202 of 8  
jigr1432133212 of 8  
hng2522938232 of 8  
Adf1618241242 of 8  
CG3919715432212 of 8  
hng189551342 of 8  
CG10949910746212 of 8  
CG4404109146232 of 8  

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal body size | first instar larval stage
decreased rate of movement | first instar larval stage
embryonic/first instar larval cuticle
embryonic/first instar larval cuticle | germline clone
lethal | first instar larval stage
lethal | first instar larval stage | germline clone
viable
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Disease Associations

Cases where the expected disease association was NOT found
all annotationsall disease by infectious agentbacterial infectious diseasefungal infectious diseaseparasitic infectious diseaseviral infectious diseaseall disease of anatomical entitycardiovascular system diseasecentral nervous system diseaseendocrine system diseasegastrointestinal system diseasehematopoietic system diseaseimmune system diseaseintegumentary system diseasemusculoskeletal system diseaseperipheral nervous system diseasereproductive system diseaserespiratory system diseasesensory system diseasethoracic diseaseurinary system diseaseall disease of cellular proliferationbenign neoplasmcancerpre-malignant neoplasmall genetic diseasechromosomal diseasemonogenic diseasepolygenic diseaseall other diseasedisease of mental healthdisease of metabolismphysical disordersyndrome
Mes2 (Dme)
Cell color indicative of annotation volume
No data available

Alleles and Variants

Genome location
Assembly version
R6
Viewer Help
22.946M22.947M22.948M22.949M22.950M22.951M22.952M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
Mes2MI06804
  • Mes2[MI06804]
allele with one associated variant
insertion
  • 3 prime UTR variant
Mes2f01255
  • Mes2[f01255]
allele with one associated variant
Mes201
  • Mes2[01]
allele with one associated variantYes
Mes2d10836
  • Mes2[d10836]
allele with one associated variant
Mes2d01660
  • Mes2[d01660]
allele with one associated variant
insertion
  • intron variant
Mes2d02763
  • Mes2[d02763]
allele with one associated variant
Mes2MB07230
  • Mes2[MB07230]
allele with one associated variant
insertion
  • intron variant
Mes2d11349
  • Mes2[d11349]
allele with one associated variant
insertion
  • intron variant
Mes2d11440
  • Mes2[d11440]
allele with one associated variant
Mes2d07515
  • Mes2[d07515]
allele with one associated variant
insertion
  • intron variant
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Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Drosophila melanogasterMes2+t12
Drosophila melanogasterMes2GD4628
  • UASt
Drosophila melanogasterMes2GFP.FPTB
  • Mes2 (Dme)
  • sfGFP
  • Tag:BLRP
  • Tag:CS(PSP)
  • Tag:CS(TEVp)
  • Tag:FLAG
Drosophila melanogasterMes2HMS00460
  • UAS
Drosophila melanogasterMes2KK115780
  • UASt
Drosophila melanogasterMes2NIG.11100R
  • UASt
Drosophila melanogasterMes2UAS.ORF.Tag:HA
  • UASt
Drosophila melanogasterMes2UAS.ORF
  • UASt
Drosophila melanogasterMes2UAS.cZa
  • UASt
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Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
22.946M22.947M22.948M22.949M22.950M22.951M22.952MMes2-RB (Mes2)Mes2-RC (Mes2)

Sequence Details

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Expression

Primary Sources
Other Sources
all annotationsall anatomical structuresalimentary part of gastrointestinal systemchemosensory systemcirculatory systemendocrine systemexocrine systemhemolymphoid systemhepatobiliary systemintegumental systemmechanosensory systemmusculoskeletal systemnervous systemrenal systemreproductive systemrespiratory systemsensory systemvestibulo-auditory systemvisual systemendodermectodermmesodermmesenchymeadipose tissueappendageentire extraembryonic componentimaginal precursorpharyngeal archotherall stagesembryo stagepost embryonic, pre-adultpost-juvenile adult stageall cellular componentsextracellular regionplasma membranesynapsecell junctioncell projectioncytoplasmic vesicleendosomevacuolegolgi apparatusendoplasmic reticulumcytosolmitochondrionnucleuschromosomecytoskeletonprotein-containing complexother locations
Mes2 (Dme)
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

22 interactor genes based on 23 annotations
Mes2 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
Atg16Drosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
CG3081Drosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
CG6707Drosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
CG11768Drosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
CG12768Drosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
protein
CG15564Drosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
Cp18Drosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
CtBPDrosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
protein
Echs1Drosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
protein
eIF4BDrosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
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Genetic Interactions

No data available