Involved in several processes, including compound eye development; endomitotic cell cycle; and regulation of protein stability. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including anterior endoderm; central brain primordium; egg chamber; embryonic/larval midgut primordium; and follicle cell. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human SKP2 (S-phase kinase associated protein 2).
FB Description
S-phase kinase-associated protein 2 (Skp2) encodes the substrate recognizing component of the SCF-Skp2 ubiquitin ligase. It functions with the product of Cks85A to target the product of dap for destruction. It is required for larval growth and to maintain diploidy in imaginal tissues.