Gene

Skp2

Species
Drosophila melanogaster
Symbol
Skp2
Name
S-phase kinase-associated protein 2
Synonyms
  • 153298_at
  • CG9772
Biotype
protein coding gene
Automated Description
Involved in several processes, including compound eye development; endomitotic cell cycle; and regulation of protein stability. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including anterior endoderm; central brain primordium; egg chamber; embryonic/larval midgut primordium; and follicle cell. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human SKP2 (S-phase kinase associated protein 2).
FB Description
S-phase kinase-associated protein 2 (Skp2) encodes the substrate recognizing component of the SCF-Skp2 ubiquitin ligase. It functions with the product of Cks85A to target the product of dap for destruction. It is required for larval growth and to maintain diploidy in imaginal tissues.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR16134
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
4.3350M4.3355M4.3360M4.3365M4.3370M4.3375M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions