Version: 8.0.0
Date: Tue Jan 28 2025
sea
Drosophila melanogasterFB:FBgn0037912
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

sea

Species
Drosophila melanogaster
Symbol
sea
Name
scheggia
Synonyms
  • anon-WO0140519.12
  • CG31305
Biotype
protein coding gene
Automated Description
Predicted to enable citrate secondary active transmembrane transporter activity. Involved in mitochondrial citrate transmembrane transport. Located in Nebenkern and mitochondrion. Is expressed in Nebenkern; adult head; adult heart; larval neuroblast; and organism. Used to study DiGeorge syndrome; combined D-2- and L-2-hydroxyglutaric aciduria; and mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in 2-hydroxyglutaric aciduria; combined D-2- and L-2-hydroxyglutaric aciduria; and congenital myasthenic syndrome. Orthologous to human SLC25A1 (solute carrier family 25 member 1).
FB Description
scheggia (sea) encodes a carrier protein of the inner mitochondrial membrane that plays a central role in fatty acid and sterol biosynthesis. It catalyses an electroneutral exchange of citrate for another tricarboxylate, a dicarboxylate (L-malate), or phosphoenolpyruvate across the inner mitochondrial membrane. The product of sea is also required to prevent chromosome breaks.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45788
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          sea molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            sea role
            sea genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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