Predicted to enable rRNA (uridine-2'-O-)-methyltransferase activity. Involved in mitochondrial large ribosomal subunit assembly. Predicted to be active in mitochondrion. Is expressed in adult head and organism. Used to study mitochondrial DNA depletion syndrome 17. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 17. Orthologous to human MRM2 (mitochondrial rRNA methyltransferase 2).