Gene

Usp8

Species
Drosophila melanogaster
Symbol
Usp8
Name
Ubiquitin specific protease 8
Synonyms
  • CG5798
  • CT18196
Biotype
protein coding gene
Automated Description
Enables cysteine-type deubiquitinase activity. Involved in several processes, including negative regulation of lysosomal protein catabolic process; neuron remodeling; and positive regulation of signal transduction. Located in cytosol. Is expressed in adult head and eye. Human ortholog(s) of this gene implicated in ACTH-secreting pituitary adenoma. Orthologous to human USP8 (ubiquitin specific peptidase 8).
FB Description
Ubiquitin specific protease 8 (Usp8) encodes a protease involved in protein deubiquitination. It contributes to the integrity of ESCRT sorting machinery and the regulation of Hedgehog and Wingless signaling pathways.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR21646
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
21.1345M21.1350M21.1355M21.1360M21.1365M21.1370M21.1375M21.1380M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions