Enables cysteine-type deubiquitinase activity. Involved in several processes, including negative regulation of lysosomal protein catabolic process; neuron remodeling; and positive regulation of signal transduction. Located in cytosol. Is expressed in adult head and eye. Human ortholog(s) of this gene implicated in ACTH-secreting pituitary adenoma. Orthologous to human USP8 (ubiquitin specific peptidase 8).
FB Description
Ubiquitin specific protease 8 (Usp8) encodes a protease involved in protein deubiquitination. It contributes to the integrity of ESCRT sorting machinery and the regulation of Hedgehog and Wingless signaling pathways.