Enables ecdysis-triggering hormone receptor activity. Involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in larval midline neurons; midline glial cell; neurons; pupal central nervous system; and ventral midline of embryo. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 7 and hypertension. Orthologous to human TRHR (thyrotropin releasing hormone receptor).
FB Description
ETHR (ETHR) encodes two distinct G protein-coupled receptors through alternative splicing. During development, the receptors are essential in initiating the molt-related behaviors of ecdysis, and in adults they function to promote juvenile hormone signaling and reproduction.