Gene

ETHR

Species
Drosophila melanogaster
Symbol
ETHR
Name
ETHR
Synonyms
  • anon-WO0170980.37
  • anon-WO0170980.38
Biotype
protein coding gene
Automated Description
Enables ecdysis-triggering hormone receptor activity. Involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in larval midline neurons; midline glial cell; neurons; pupal central nervous system; and ventral midline of embryo. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 7 and hypertension. Orthologous to human TRHR (thyrotropin releasing hormone receptor).
FB Description
ETHR (ETHR) encodes two distinct G protein-coupled receptors through alternative splicing. During development, the receptors are essential in initiating the molt-related behaviors of ecdysis, and in adults they function to promote juvenile hormone signaling and reproduction.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24243
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
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21.248M21.250M21.252M21.254M21.256M21.258M21.260M21.262M21.264M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions