Gene

Nrx-1

Species
Drosophila melanogaster
Symbol
Nrx-1
Name
Neurexin 1
Synonyms
  • CG7050
  • CT21808
Biotype
protein coding gene
Automated Description
Enables apolipoprotein binding activity; protein kinase binding activity; and signaling receptor binding activity. Involved in several processes, including neuromuscular synaptic transmission; positive regulation of synaptic vesicle endocytosis; and synapse organization. Located in neuromuscular junction; presynaptic membrane; and type I terminal bouton. Part of trans-synaptic protein complex. Is expressed in several structures, including NMJ bouton; adult head; adult mushroom body; brain; and synaptic neuropil domain. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in Pitt-Hopkins-like syndrome 2; alcohol dependence; and nicotine dependence. Orthologous to several human genes including NRXN2 (neurexin 2).
FB Description
Neurexin 1 (Nrx-1) encodes a transmembrane synaptic adhesive molecule that regulates the synaptic architecture and function in the brain and neuromuscular junction. It contributes to synaptic growth, transmission, synaptic formation and also regulation of learning and memory, locomotion and visual function.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR15036
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
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22.470M22.472M22.474M22.476M22.478M22.480M22.482M22.484M22.486M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions