Enables apolipoprotein binding activity; protein kinase binding activity; and signaling receptor binding activity. Involved in several processes, including neuromuscular synaptic transmission; positive regulation of synaptic vesicle endocytosis; and synapse organization. Located in neuromuscular junction; presynaptic membrane; and type I terminal bouton. Part of trans-synaptic protein complex. Is expressed in several structures, including NMJ bouton; adult head; adult mushroom body; brain; and synaptic neuropil domain. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in Pitt-Hopkins-like syndrome 2; alcohol dependence; and nicotine dependence. Orthologous to several human genes including NRXN2 (neurexin 2).
FB Description
Neurexin 1 (Nrx-1) encodes a transmembrane synaptic adhesive molecule that regulates the synaptic architecture and function in the brain and neuromuscular junction. It contributes to synaptic growth, transmission, synaptic formation and also regulation of learning and memory, locomotion and visual function.