Version: 8.0.0
Date: Tue Jan 28 2025
spas
Drosophila melanogasterFB:FBgn0039141
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

spas

Species
Drosophila melanogaster
Symbol
spas
Name
spastin
Synonyms
  • CG5977
  • D-Spastin
Biotype
protein coding gene
Automated Description
Enables microtubule binding activity and microtubule severing ATPase activity. Involved in several processes, including regulation of microtubule depolymerization; regulation of nervous system development; and regulation of neuromuscular synaptic transmission. Located in several cellular components, including centrosome; neuromuscular junction; and terminal bouton. Colocalizes with synaptic vesicle. Is expressed in several structures, including anterior midgut primordium; cephalic furrow; embryonic neuromere; embryonic/larval head sense organ; and ganglia. Used to study hereditary spastic paraplegia and hereditary spastic paraplegia 4. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 4. Orthologous to human SPAST (spastin).
FB Description
spastin (spas) encodes a member of the AAA ATPase family that assembles into hexamers and severs microtubules along their lengths. The microtubule binding and severing activities of the product of spas are dependent upon tubulin glutamylation levels. Its proposed roles include mitosis, axon transport, synapse formation, dendrite arborization, organelle tubulation, and lipid droplet metabolism.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23074
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          spas molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
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            Genetic Interactions

            spas role
            spas genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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