Gene

spas

Species
Drosophila melanogaster
Symbol
spas
Name
spastin
Synonyms
  • CG5977
  • D-Spastin
Biotype
protein coding gene
Automated Description
Enables microtubule binding activity and microtubule severing ATPase activity. Involved in several processes, including regulation of microtubule depolymerization; regulation of nervous system development; and regulation of neuromuscular synaptic transmission. Located in several cellular components, including centrosome; neuromuscular junction; and terminal bouton. Colocalizes with synaptic vesicle. Is expressed in several structures, including anterior midgut primordium; cephalic furrow; embryonic neuromere; embryonic/larval head sense organ; and ganglia. Used to study hereditary spastic paraplegia and hereditary spastic paraplegia 4. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 4. Orthologous to human SPAST (spastin).
FB Description
spastin (spas) encodes a member of the AAA ATPase family that assembles into hexamers and severs microtubules along their lengths. The microtubule binding and severing activities of the product of spas are dependent upon tubulin glutamylation levels. Its proposed roles include mitosis, axon transport, synapse formation, dendrite arborization, organelle tubulation, and lipid droplet metabolism.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23074
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
24.0385M24.0390M24.0395M24.0400M24.0405M24.0410M24.0415M24.0420M24.0425M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions