Enables RNA endonuclease activity and RNA exonuclease activity. Involved in several processes, including defense response to virus; mitotic cell cycle; and nuclear RNA surveillance. Located in nuclear lamina. Part of nuclear exosome (RNase complex). Is expressed in adult head; mesoderm; nurse cell; oocyte; and organism. Used to study multiple myeloma and primary ovarian insufficiency. Orthologous to human DIS3 (DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease).
FB Description
Dis3 (Dis3) encodes an exoribonuclease that forms part of the RNA processing exosome complex. It is involved in the regulation of cell cycle progresion, microRNA expression and mRNA surveillance.