Gene

Dis3

Species
Drosophila melanogaster
Symbol
Dis3
Name
Dis3
Synonyms
  • CG6413
  • dDis3
Biotype
protein coding gene
Automated Description
Enables RNA endonuclease activity and RNA exonuclease activity. Involved in several processes, including defense response to virus; mitotic cell cycle; and nuclear RNA surveillance. Located in nuclear lamina. Part of nuclear exosome (RNase complex). Is expressed in adult head; mesoderm; nurse cell; oocyte; and organism. Used to study multiple myeloma and primary ovarian insufficiency. Orthologous to human DIS3 (DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease).
FB Description
Dis3 (Dis3) encodes an exoribonuclease that forms part of the RNA processing exosome complex. It is involved in the regulation of cell cycle progresion, microRNA expression and mRNA surveillance.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23355
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
24.3335M24.3340M24.3345M24.3350M24.3355M24.3360M24.3365M24.3370M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions