Gene

Vps16B

Species
Drosophila melanogaster
Symbol
Vps16B
Name
Vacuolar protein sorting 16B
Synonyms
  • CG18112
  • dVps16B
Biotype
protein coding gene
Automated Description
Involved in cellular response to peptidoglycan; immune response; and phagosome-lysosome fusion. Part of HOPS complex. Used to study ARC syndrome. Human ortholog(s) of this gene implicated in arthrogryposis, renal dysfunction, and cholestasis 2. Orthologous to human VIPAS39 (VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog).
FB Description
Vacuolar protein sorting 16B (Vps16B) encodes a protein that, together with its binding partner encoded by Vps33B, forms a distinct complex necessary for fusions between phagosomes and lysosomes.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13364
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensVIPAS398 of 9YesYes   
Mus musculusVipas397 of 9YesYes   
Rattus norvegicusVipas398 of 9YesYes   
Xenopus tropicalisvipas395 of 9YesYes   
Danio reriovipas398 of 10YesYes  
Caenorhabditis elegansspe-396 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal immune response
fertile
hemocyte
short lived | conditional
viable
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
R6
Viewer Help
29.8150M29.8152M29.8154M29.8156M29.8158M29.8160M29.8162M29.8164M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
Vps16B1
  • fob[1]
  • fob1
allele
YesYes
NT_033777.3:g.29816381C>Tvariant
SNP
  • missense variant
NT_033777.3:g.29816442T>Cvariant
SNP
  • 5 prime UTR variant
NT_033777.3:g.29816451C>Tvariant
SNP
  • 5 prime UTR variant
NT_033777.3:g.29816127G>Tvariant
SNP
  • missense variant
NT_033777.3:g.29816152A>Gvariant
SNP
  • synonymous variant
NT_033777.3:g.29815045A>Tvariant
SNP
  • 3 prime UTR variant
NT_033777.3:g.29815081G>Avariant
SNP
  • synonymous variant
NT_033777.3:g.29815633C>Avariant
SNP
  • missense variant
NT_033777.3:g.29815537C>Tvariant
SNP
  • synonymous variant
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Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Drosophila melanogasterVps16B+t
Drosophila melanogasterVps16BGD9513
  • UASt
Drosophila melanogasterVps16BHMS01732
  • UAS
Drosophila melanogasterVps16BKK107970
  • UASt
Drosophila melanogasterVps16BNIG.18112R
  • UASt
Drosophila melanogasterVps16BUAS.Tag:MYC
  • UAS
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Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
29.8150M29.8152M29.8154M29.8156M29.8158M29.8160M29.8162M29.8164MVps16B-RA (Vps16B)ca-RA (ca)ca-RC (ca)

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

4 interactor genes based on 6 annotations
Vps16B molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
CG15109Drosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
dorDrosophila melanogaster
protein
  • anti bait coimmunoprecipitation
PMID:16046475
protein
DysDrosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
Vps33BDrosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
Vps33BDrosophila melanogaster
protein
  • anti tag coimmunoprecipitation
PMID:16046475
protein
Vps33BDrosophila melanogaster
protein
  • anti tag coimmunoprecipitation
PMID:21282466
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Genetic Interactions

No data available