Gene

Sas-6

Species
Drosophila melanogaster
Symbol
Sas-6
Name
Spindle assembly abnormal 6
Synonyms
  • CG15524
  • DSAS-6
Biotype
protein coding gene
Automated Description
Involved in microtubule organizing center organization and protein localization to centrosome. Located in centriole; centrosome; and ciliary basal body. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 14. Orthologous to human SASS6 (SAS-6 centriolar assembly protein).
FB Description
Spindle assembly abnormal 6 (Sas-6) encodes a centriole protein that is essential for centriole assembly. It can homo-oligomerise to form a 9-fold symmetric "cartwheel" structure that plays an important part in setting the 9-fold symmetry of the assembling centriole.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR44281
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
29.9954M29.9956M29.9958M29.9960M29.9962M29.9964M29.9966M29.9968M29.9970M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions