Involved in microtubule organizing center organization and protein localization to centrosome. Located in centriole; centrosome; and ciliary basal body. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 14. Orthologous to human SASS6 (SAS-6 centriolar assembly protein).
FB Description
Spindle assembly abnormal 6 (Sas-6) encodes a centriole protein that is essential for centriole assembly. It can homo-oligomerise to form a 9-fold symmetric "cartwheel" structure that plays an important part in setting the 9-fold symmetry of the assembling centriole.