Enables glutamate-cysteine ligase activity. Involved in several processes, including glutathione biosynthetic process; imaginal disc-derived wing morphogenesis; and response to copper ion. Located in nucleus and perinuclear region of cytoplasm. Part of glutamate-cysteine ligase complex. Is expressed in embryonic/larval midgut; organism; and posterior midgut primordium. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia 7; cystic fibrosis; hemolytic anemia; and myocardial infarction. Orthologous to human GCLC (glutamate-cysteine ligase catalytic subunit).
FB Description
Glutamate-cysteine ligase catalytic subunit (Gclc) encodes a heterodimeric enzyme involved in the first rate-limiting step of glutathione synthesis. It binds L-cysteine and L-glutamate to form gamma-glutamylcysteine.