Gene

Gclc

Species
Drosophila melanogaster
Symbol
Gclc
Name
Glutamate-cysteine ligase catalytic subunit
Synonyms
  • 2259
  • catalytic subunit of glutamate- cysteine ligase
Biotype
protein coding gene
Automated Description
Enables glutamate-cysteine ligase activity. Involved in several processes, including glutathione biosynthetic process; imaginal disc-derived wing morphogenesis; and response to copper ion. Located in nucleus and perinuclear region of cytoplasm. Part of glutamate-cysteine ligase complex. Is expressed in embryonic/larval midgut; organism; and posterior midgut primordium. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia 7; cystic fibrosis; hemolytic anemia; and myocardial infarction. Orthologous to human GCLC (glutamate-cysteine ligase catalytic subunit).
FB Description
Glutamate-cysteine ligase catalytic subunit (Gclc) encodes a heterodimeric enzyme involved in the first rate-limiting step of glutathione synthesis. It binds L-cysteine and L-glutamate to form gamma-glutamylcysteine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11164
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
8.104M8.106M8.108M8.110M8.112M8.114M8.116M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions