Version: 8.0.0
Date: Tue Jan 28 2025
Gclc
Drosophila melanogasterFB:FBgn0040319
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Gclc

Species
Drosophila melanogaster
Symbol
Gclc
Name
Glutamate-cysteine ligase catalytic subunit
Synonyms
  • 2259
  • catalytic subunit of glutamate- cysteine ligase
Biotype
protein coding gene
Automated Description
Enables glutamate-cysteine ligase activity. Involved in several processes, including glutathione biosynthetic process; imaginal disc-derived wing morphogenesis; and response to copper ion. Located in nucleus and perinuclear region of cytoplasm. Part of glutamate-cysteine ligase complex. Is expressed in embryonic/larval midgut; organism; and posterior midgut primordium. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia 7; cystic fibrosis; hemolytic anemia; and myocardial infarction. Orthologous to human GCLC (glutamate-cysteine ligase catalytic subunit).
FB Description
Glutamate-cysteine ligase catalytic subunit (Gclc) encodes a heterodimeric enzyme involved in the first rate-limiting step of glutathione synthesis. It binds L-cysteine and L-glutamate to form gamma-glutamylcysteine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11164
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Gclc molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
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            Genetic Interactions

            Gclc role
            Gclc genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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