Version: 8.0.0
Date: Tue Jan 28 2025
Hex-t2
Drosophila melanogasterFB:FBgn0042710
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Hex-t2

Species
Drosophila melanogaster
Symbol
Hex-t2
Name
Hexokinase testis 2
Synonyms
  • anon-WO0140519.203
  • CG32849
Biotype
protein coding gene
Automated Description
Predicted to enable fructokinase activity and glucokinase activity. Predicted to be involved in glucose 6-phosphate metabolic process; hexose metabolic process; and intracellular glucose homeostasis. Predicted to be active in cytosol and mitochondrion. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 4G; anemia (multiple); artery disease (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Orthologous to several human genes including GCK (glucokinase); HK2 (hexokinase 2); and HK3 (hexokinase 3).
FB Description
Hexokinase testis 2 (Hex-t2) is predicted to encode a testis-specific enzyme involved in hexose metabolism that catalyzes the phosphorylation of hexose to hexose 6-phosphate. It may mediate the initial step of glycolysis by catalyzing the phosphorylation of D-glucose to D-glucose 6-phosphate.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR19443
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Hex-t2 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Hex-t2 role
            Hex-t2 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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