Predicted to enable fructokinase activity and glucokinase activity. Predicted to be involved in glucose 6-phosphate metabolic process; hexose metabolic process; and intracellular glucose homeostasis. Predicted to be active in cytosol and mitochondrion. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 4G; anemia (multiple); artery disease (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Orthologous to several human genes including GCK (glucokinase); HK2 (hexokinase 2); and HK3 (hexokinase 3).
FB Description
Hexokinase testis 2 (Hex-t2) is predicted to encode a testis-specific enzyme involved in hexose metabolism that catalyzes the phosphorylation of hexose to hexose 6-phosphate. It may mediate the initial step of glycolysis by catalyzing the phosphorylation of D-glucose to D-glucose 6-phosphate.