Version: 8.0.0
Date: Tue Jan 28 2025
Fsn
Drosophila melanogasterFB:FBgn0043010
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Fsn

Species
Drosophila melanogaster
Symbol
Fsn
Name
F-box synaptic protein
Synonyms
  • BEST:GH20696
  • CG4643
Biotype
protein coding gene
Automated Description
Involved in negative regulation of synaptic assembly at neuromuscular junction; neuromuscular synaptic transmission; and regulation of macromolecule metabolic process. Located in several cellular components, including cell cortex; neuromuscular junction; and pole plasm. Part of SCF ubiquitin ligase complex. Is expressed in organism. Orthologous to human FBXO45 (F-box protein 45).
FB Description
F-box synaptic protein (Fsn) encodes an F-box protein that forms a ubiquitin ligase complex with the E3 ligase and the Skp protein encoded by hiw and SkpA, respectively. Its key substrates are the products of wnd and Nmnat.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12245
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
            Viewer Help
            Data currently unavailable; sequence viewer under construction

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Fsn molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              Fsn role
              Fsn genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
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