Gene

bchs

Species
Drosophila melanogaster
Symbol
bchs
Name
blue cheese
Synonyms
  • Alfy
  • alfy
Biotype
protein coding gene
Automated Description
Predicted to enable metal ion binding activity. Involved in several processes, including autophagosome assembly; nervous system development; and positive regulation of organ growth. Located in lysosome; neuromuscular junction; and presynaptic active zone. Is expressed in several structures, including adult head; larval central nervous system; larval internal muscle motor neurons; larval muscle system; and spermatozoon. Used to study autism spectrum disorder and primary autosomal dominant microcephaly 18. Human ortholog(s) of this gene implicated in primary autosomal dominant microcephaly 18. Orthologous to human WDFY3 (WD repeat and FYVE domain containing 3).
FB Description
blue cheese (bchs) is a neuronally expressed gene that encodes a member of the BEACH (Beige and Chediak-Higashi)-domain superfamily, whose members are involved in vesicle trafficking. It antagonizes the activity of the product of Rab11. It serves as a scaffold for autophagy proteins, and contributes to ref(2)P-mediated aggrephagy. It contributes to nervous system development, lysosome transport and sphingolipid metabolism.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46108
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
5.908M5.910M5.912M5.914M5.916M5.918M5.920M5.922M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions