Version: 8.0.0
Date: Tue Jan 28 2025
AIMP3
Drosophila melanogasterFB:FBgn0050185
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

AIMP3

Species
Drosophila melanogaster
Symbol
AIMP3
Name
aaRS-interacting multifunctional protein 3
Synonyms
  • aminoacyl-tRNA synthetase-interacting multifunctional protein 3
  • anon-EST:Posey25
Biotype
protein coding gene
Automated Description
Predicted to be involved in positive regulation of DNA damage response, signal transduction by p53 class mediator. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Predicted to be active in cytoplasm and nucleus. Is expressed in organism. Orthologous to human EEF1E1 (eukaryotic translation elongation factor 1 epsilon 1).
FB Description
aaRS-interacting multifunctional protein 3 (AIMP3) is predicted to encode one of 3 non-enzymatic factors that combine with eight aminoacyl-tRNA synthetases to form a 'multi-synthetase complex' (MSC). The functional significance of the MSC is unclear, but the non-enzymatic factors are thought to be responsive to diverse signal transduction pathways.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR44490
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          AIMP3 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            AIMP3 role
            AIMP3 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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