Enables glucosylceramidase activity. Involved in several processes, including adult locomotory behavior; cellular response to unfolded protein; and determination of adult lifespan. Is expressed in adult head. Used to study Gaucher's disease; Lewy body dementia; and Parkinson's disease. Human ortholog(s) of this gene implicated in Gaucher's disease (multiple); Lewy body dementia; Parkinson's disease (multiple); and Parkinsonism. Orthologous to human GBA1 (glucosylceramidase beta 1).
FB Description
Glucocerebrosidase 1b (Gba1b) encodes a lysosomal acid beta glucocerebrosidase that catalyzes the hydrolysis of glucosylceramide to ceramide and glucose.