Gene

Gba1b

Species
Drosophila melanogaster
Symbol
Gba1b
Name
Glucocerebrosidase 1b
Synonyms
  • CG10299
  • CG31414
Biotype
protein coding gene
Automated Description
Enables glucosylceramidase activity. Involved in several processes, including adult locomotory behavior; cellular response to unfolded protein; and determination of adult lifespan. Is expressed in adult head. Used to study Gaucher's disease; Lewy body dementia; and Parkinson's disease. Human ortholog(s) of this gene implicated in Gaucher's disease (multiple); Lewy body dementia; Parkinson's disease (multiple); and Parkinsonism. Orthologous to human GBA1 (glucosylceramidase beta 1).
FB Description
Glucocerebrosidase 1b (Gba1b) encodes a lysosomal acid beta glucocerebrosidase that catalyzes the hydrolysis of glucosylceramide to ceramide and glucose.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11069
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
23.7050M23.7055M23.7060M23.7065M23.7070M23.7075M23.7080M23.7085M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions