Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in proboscis development; specification of segmental identity, labial segment; and specification of segmental identity, maxillary segment. Located in nucleus. Is expressed in several structures, including anterior ectoderm; embryonic segment; embryonic/larval foregut; ganglia; and labial disc. Orthologous to human HOXA2 (homeobox A2) and HOXB2 (homeobox B2).
FB Description
proboscipedia (pb) encodes a conserved homeodomain transcription factor. Its role in regional head development, from insects to mammals, likely involves combinatorial regulation both of cell-specific targets and of multiple signaling pathways.