Gene

pb

Species
Drosophila melanogaster
Symbol
pb
Name
proboscipedia
Synonyms
  • BG:DS01719.1
  • CG17880
Biotype
protein coding gene
Automated Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in proboscis development; specification of segmental identity, labial segment; and specification of segmental identity, maxillary segment. Located in nucleus. Is expressed in several structures, including anterior ectoderm; embryonic segment; embryonic/larval foregut; ganglia; and labial disc. Orthologous to human HOXA2 (homeobox A2) and HOXB2 (homeobox B2).
FB Description
proboscipedia (pb) encodes a conserved homeodomain transcription factor. Its role in regional head development, from insects to mammals, likely involves combinatorial regulation both of cell-specific targets and of multiple signaling pathways.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45664
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
6.710M6.715M6.720M6.725M6.730M6.735M6.740M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions