Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryonic midgut chamber; embryonic/larval midgut; and posterior midgut primordium. Human ortholog(s) of this gene implicated in acute myeloid leukemia; gray platelet syndrome; myelodysplastic syndrome; platelet-type bleeding disorder 17; and severe congenital neutropenia 2. Orthologous to several human genes including GFI1B (growth factor independent 1B transcriptional repressor).