Version: 8.0.0
Date: Tue Jan 28 2025
Cnot4
Drosophila melanogasterFB:FBgn0051716
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Cnot4

Species
Drosophila melanogaster
Symbol
Cnot4
Name
CCR4-NOT transcription complex subunit 4
Synonyms
  • CCR4
  • CCR4-NOT
Biotype
protein coding gene
Automated Description
Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in cytoplasm. Predicted to be part of CCR4-NOT complex. Is expressed in organism; pole plasm; and primordial germ cell. Used to study heart disease. Orthologous to human CNOT4 (CCR4-NOT transcription complex subunit 4).
FB Description
CCR4-NOT transcription complex subunit 4 (Cnot4) encodes a positive regulator of the Jak/Stat pathway which acts by stabilizing the DNA binding of the product of Stat92E.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12603
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
            Viewer Help
            10.397M10.398M10.399M10.400M10.401M10.402M10.403M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Cnot4 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              Cnot4 role
              Cnot4 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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