Gene

Ptip

Species
Drosophila melanogaster
Symbol
Ptip
Name
PAX transcription activation domain interacting protein
Synonyms
  • CG32133
  • CG6532
Biotype
protein coding gene
Automated Description
Involved in anterior/posterior pattern specification, imaginal disc; embryonic pattern specification; and positive regulation of antibacterial peptide biosynthetic process. Part of MLL3/4 complex. Is expressed in several structures, including gland; gut section; imaginal disc; larval central nervous system; and larval ventral nerve cord. Orthologous to human PAXIP1 (PAX interacting protein 1).
FB Description
PAX transcription activation domain interacting protein (Ptip) encodes a component of a Histone H3K4 methyltransferase complex that contributes to Trithorax-mediated epigenetic imprinting during development.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23196
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensPAXIP15 of 9YesYes   
Mus musculusPaxip15 of 9YesYes   
Rattus norvegicusPaxip15 of 9YesYes   
Xenopus tropicalispaxip13 of 9YesYes   
Danio reriopaxip13 of 10YesYes  
Caenorhabditis eleganspis-16 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
lethal | recessive
ventral denticle belt | germline clone | maternal effect
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
R6
Viewer Help
14.021M14.022M14.023M14.024M14.025M14.026M14.027M14.028M14.029M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
PtipTag:FLAG
  • Ptip[Tag:FLAG]
allele
PtipCR02859-TG4.0
  • Ptip[CR02859-TG4.0]
allele
Ptipc04574
  • CG32133[c04574]
  • CG32133c04574
allele with one associated variant
insertion
  • coding sequence variant
Yes
Ptip3804
  • ptip[3804]
  • Ptip[3804]
allele with one associated variant
point mutation
  • stop gained
PtipMI03338
  • Ptip[MI03338]
  • ptip[MI03338]
allele with one associated variant
insertion
  • coding sequence variant
PtipMB03779
  • CG32133[MB03779]
  • CG32133MB03779
allele with one associated variant
insertion
  • coding sequence variant
Ptip324
  • Ptip[324]
allele with one associated variant
point mutation
  • stop gained
Ptipc450
  • Ptip[c450]
allele with one associated variant
deletion
  • inframe deletion
PtipΔ13
  • Ptip[Delta13]
  • ptip[Delta13]
allele with one associated variant
deletion
  • splice donor variant
PtipMB08895
  • CG32133[MB08895]
  • CG32133MB08895
allele with one associated variant
insertion
  • coding sequence variant
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Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Drosophila melanogasterPtipGD4399
  • UASt
Drosophila melanogasterPtipGL00167
  • UAS
Drosophila melanogasterPtipHM04051
  • UAS
Drosophila melanogasterPtipNIG.32133R
  • UASt
Drosophila melanogasterPtipTOE.GS02821
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Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
14.021M14.022M14.023M14.024M14.025M14.026M14.027M14.028M14.029MPtip-RA (Ptip)

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

36 interactor genes based on 37 annotations
Ptip molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
agoDrosophila melanogaster
protein
  • two hybrid
PMID:15710747
protein
ash2Drosophila melanogaster
protein
  • anti tag coimmunoprecipitation
PMID:21875999
protein
Bap60Drosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
protein
bocaDrosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
protein
brmDrosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
protein
Cdk8Drosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
protein
CG3008Drosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
protein
CG17002Drosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
protein
CG34159Drosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
protein
Cpsf6Drosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
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Genetic Interactions

No data available