Gene

SMSr

Species
Drosophila melanogaster
Symbol
SMSr
Name
Sphingomyelin synthase related
Synonyms
  • CG32380
  • CG8572
Biotype
protein coding gene
Automated Description
Enables ceramide cholinephosphotransferase activity and sphingomyelin synthase activity. Involved in ceramide biosynthetic process and regulation of ceramide biosynthetic process. Located in endoplasmic reticulum membrane. Is expressed in adult head and organism. Orthologous to human SAMD8 (sterile alpha motif domain containing 8).
FB Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR21290
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensSAMD88 of 9YesYes   
Mus musculusSamd88 of 9YesYes   
Rattus norvegicusSamd88 of 9YesYes   
Xenopus tropicalissamd88 of 9YesYes   
Danio reriosamd88 of 10YesYes  
Caenorhabditis elegansF53B1.28 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
fertile
viable
Showing 1 - 2 of 2 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
R6
Viewer Help
7.375M7.376M7.377M7.378M7.379M7.380M7.381M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
SMSrGS-A2330
  • SMSr[GS-A2330]
allele
SMSrNP3043
  • SMSr[NP3043]
allele with one associated variant
insertion
  • 5 prime UTR variant
SMSrPL00377
  • SMSr[PL00377]
allele with one associated variant
insertion
  • intron variant
Yes
SMSr1
  • dSMSr[1]
  • dSMSr1
allele with one associated variant
deletion
  • 5 prime UTR variant
SMSrf01601
  • SMSr[f01601]
allele with one associated variant
insertion
  • coding sequence variant
SMSr0374-G4
  • SMSr[0374-G4]
allele with one associated variant
insertion
  • intron variant
SMSrEY06091
  • SMSr[EY06091]
allele with one associated variant
insertion
  • 5 prime UTR variant
Yes
NT_037436.4:g.7374223C>Tvariant
SNP
  • 3 prime UTR variant
NT_037436.4:g.7376992C>Tvariant
SNP
  • intron variant
NT_037436.4:g.7377001C>Gvariant
SNP
  • intron variant
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Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Drosophila melanogasterSMSrGD2349
  • UASt
Drosophila melanogasterSMSrHMC06475
  • UAS
Drosophila melanogasterSMSrKK101508
  • UASt
Drosophila melanogasterSMSrNIG.8572R
  • UASt
Drosophila melanogasterSMSrUAS.ORF.Tag:HA
  • UASt
Drosophila melanogasterSMSrUAS.ORF
  • UASt
Drosophila melanogasterSMSrUAS.Tag:V5
  • UASt
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Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
7.375M7.376M7.377M7.378M7.379M7.380M7.381M

Sequence Details

Transcript: Mode:

Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

5 interactor genes based on 6 annotations
SMSr molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
CG14881Drosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
CSN4Drosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
RpLP1Drosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
yip3Drosophila melanogaster
protein
  • two hybrid
PMID:14605208
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Genetic Interactions

SMSr role
SMSr genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
enhancer gene
ctDrosophila melanogaster
enhanced gene
genetic enhancement
    PMID:15956666
    suppressor gene
    ctDrosophila melanogaster
    suppressed gene
    genetic suppression
      PMID:15956666
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