Gene

Sk2

Species
Drosophila melanogaster
Symbol
Sk2
Name
Sphingosine kinase 2
Synonyms
  • CG2159
  • CG32484
Biotype
protein coding gene
Automated Description
Enables D-erythro-sphingosine kinase activity. Involved in egg-laying behavior; flight behavior; and sphingolipid metabolic process. Located in lysosomal membrane. Is expressed in adult head; anterior midgut primordium; mesoderm; organism; and posterior midgut primordium. Used to study cardiomyopathy and obesity. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to several human genes including SPHK2 (sphingosine kinase 2).
FB Description
Sphingosine kinase 2 (Sk2) encodes a D-erythro-sphingosine kinase that contributes to sphingolipid metabolism, flight performance and ovulation.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12358
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
3.0475M3.0480M3.0485M3.0490M3.0495M3.0500M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions