Enables D-erythro-sphingosine kinase activity. Involved in egg-laying behavior; flight behavior; and sphingolipid metabolic process. Located in lysosomal membrane. Is expressed in adult head; anterior midgut primordium; mesoderm; organism; and posterior midgut primordium. Used to study cardiomyopathy and obesity. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to several human genes including SPHK2 (sphingosine kinase 2).
FB Description
Sphingosine kinase 2 (Sk2) encodes a D-erythro-sphingosine kinase that contributes to sphingolipid metabolism, flight performance and ovulation.