Gene

DIP-α

Species
Drosophila melanogaster
Symbol
DIP-α
Name
Dpr-interacting protein alpha
Synonyms
  • 32791
  • CG13019
Biotype
protein coding gene
Automated Description
Involved in synapse organization. Located in neuron projection membrane. Is expressed in ganglia; larval ventral midline glial cell; medulla; optic lobe intrinsic neurons; and ventral midline of embryo. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to several human genes including IGLON5 (IgLON family member 5); LSAMP (limbic system associated membrane protein); and NTM (neurotrimin).
FB Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12231
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
DIP-δ150255395 of 8  
DIP-β238269515 of 8  
DIP-η352149365 of 8  
DIP-θ450052355 of 8  
DIP-ε543855385 of 8  
DIP-κ642359404 of 8  
DIP-γ736862445 of 8  
DIP-ζ839856405 of 8  
DIP-λ942154375 of 8  
DIP-ι1037855374 of 8  
CG343531159039252 of 8  
robo21256934212 of 8  
Lac1332350304 of 8  
CG71661439342282 of 8  
klg1539744252 of 8  
Ama1634046272 of 8  
CG68671731547302 of 8  
fipi1839939202 of 8  
robo11933140242 of 8  
Nrg2033239232 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal neuroanatomy | adult stage
decreased cell number | adult stage
distal medullary amacrine neuron Dm1 | adult stage | decreased number
distal medullary amacrine neuron Dm12 | adult stage | decreased number
distal medullary amacrine neuron Dm4 | adult stage | decreased number
distal medullary amacrine neuron Dm4 | adult stage | increased number
increased cell number | adult stage
neuron projection | adult stage
viable
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

No mapped variant information available
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
DIP-αMI02031-Tp65AD.1
  • DIP-alpha[MI02031-Tp65AD.1]
allele
DIP-αMI02031-TQF2.1
  • DIP-alpha[MI02031-TQF2.1]
allele
DIP-α+2F
  • DIP-alpha[+2F]
allele
Yes
DIP-αhomo
  • DIP-alpha[homo]
allele
DIP-αNM
  • DIP-alpha NM
  • DIP-alpha[NM]
allele
DIP-αT2A-GAL4
  • DIP-alpha[T2A-GAL4]
allele
DIP-α-20F
  • DIP-alpha[-20F]
allele
Yes
DIP-αNectin1.Y172K.L116E
  • DIP-alpha[Nectin1.Y172K.L116E]
allele
DIP-αPRP
  • DIP-alpha-PRP
  • DIP-alpha[PRP]
allele
DIP-αhet-homo
  • DIP-alpha[het-homo]
  • DIP-alpha[homo-het]
allele
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Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Drosophila melanogasterDIP-αGD16826
  • UASt
Drosophila melanogasterDIP-αGD7594
  • UASt
Drosophila melanogasterDIP-αGD7902
  • UASt
Drosophila melanogasterDIP-αI83A.UAS.Tag:MYC
  • UASt
Drosophila melanogasterDIP-αKK112547
  • UASt
Drosophila melanogasterDIP-αKK114238
  • UASt
Drosophila melanogasterDIP-αN.UAS.Tag:M(hCD4)
  • UASt
Drosophila melanogasterDIP-αNIG.13020R
  • UASt
Drosophila melanogasterDIP-αUAS.2A-tdTom
  • UAS
Drosophila melanogasterDIP-αUAS.Tag:MYC
  • UAS
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Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
3.51M3.52M3.53M3.54M3.55M3.56M3.57MDIP-alpha-RA (DIP-alpha)DIP-alpha-RB (DIP-alpha)DIP-alpha-RC (DIP-alpha)Myc-RA (Myc)Myc-RB (Myc)tRNA:Gln-TTG-2-1-RA (tRNA:Gln-TTG-2-1)CG14269-RA (CG14269)CG14269-RB (CG14269)CG12535-RB (CG12535)CG12535-RC (CG12535)Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.Maximum features displayed. See full view for more.

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

5 interactor genes based on 28 annotations
DIP-α molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
DIP-αDrosophila melanogaster
protein
  • cosedimentation
PMID:30467080
protein
DIP-αDrosophila melanogaster
protein
  • x-ray crystallography
PMID:30467080
protein
DIP-αDrosophila melanogaster
protein
  • cosedimentation
PMID:32358559
protein
DIP-αDrosophila melanogaster
protein
  • molecular sieving
PMID:30688651
protein
DIP-αDrosophila melanogaster
protein
  • surface plasmon resonance
PMID:35385751
protein
DIP-αDrosophila melanogaster
protein
  • enzyme linked immunosorbent assay
PMID:30688651
protein
dpr6Drosophila melanogaster
protein
  • surface plasmon resonance
PMID:23827685
protein
dpr6Drosophila melanogaster
protein
  • enzyme linked immunosorbent assay
PMID:23827685
protein
dpr6Drosophila melanogaster
protein
  • enzyme linked immunosorbent assay
PMID:23827685
protein
dpr6Drosophila melanogaster
protein
  • enzyme linked immunosorbent assay
PMID:26687361
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Genetic Interactions

DIP-α role
DIP-α genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
enhancer gene
dpr6Drosophila melanogaster
enhanced gene
genetic enhancement
    PMID:35385751
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