Enables F-actin monooxygenase activity; FAD binding activity; and actin binding activity. Involved in several processes, including actin cytoskeleton organization; neuron development; and synapse assembly involved in innervation. Located in terminal bouton. Colocalizes with plasma membrane. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval midgut primordium; larval muscle system; and larval somatic muscle cell. Orthologous to human MICAL2 (microtubule associated monooxygenase, calponin and LIM domain containing 2) and MICAL3 (microtubule associated monooxygenase, calponin and LIM domain containing 3).
FB Description
Molecule interacting with CasL (Mical) encodes a multi-domain flavoprotein monooxygenase (Redox) enzyme. It is activated by actin filaments, and then oxidizes actin on methionines 44 and 47, disassembling the actin filaments and inhibiting actin polymerization. This regulates cell morphology in the nervous system and muscle, working with the the receptor encoded by PlexA and cofilin, encoded by tsr.