Gene

Mical

Species
Drosophila melanogaster
Symbol
Mical
Name
Molecule interacting with CasL
Synonyms
  • CG11685
  • CG11687
Biotype
protein coding gene
Automated Description
Enables F-actin monooxygenase activity; FAD binding activity; and actin binding activity. Involved in several processes, including actin cytoskeleton organization; neuron development; and synapse assembly involved in innervation. Located in terminal bouton. Colocalizes with plasma membrane. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval midgut primordium; larval muscle system; and larval somatic muscle cell. Orthologous to human MICAL2 (microtubule associated monooxygenase, calponin and LIM domain containing 2) and MICAL3 (microtubule associated monooxygenase, calponin and LIM domain containing 3).
FB Description
Molecule interacting with CasL (Mical) encodes a multi-domain flavoprotein monooxygenase (Redox) enzyme. It is activated by actin filaments, and then oxidizes actin on methionines 44 and 47, disassembling the actin filaments and inhibiting actin polymerization. This regulates cell morphology in the nervous system and muscle, working with the the receptor encoded by PlexA and cofilin, encoded by tsr.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23167
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
10.005M10.010M10.015M10.020M10.025M10.030M10.035M10.040M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions