Enables co-SMAD binding activity. Involved in dendrite morphogenesis; regulation of SMAD protein signal transduction; and regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Located in cytosol and nucleus. Is expressed in several structures, including Bolwig organ; egg chamber; ganglia; and germarium. Orthologous to human SKIL (SKI like proto-oncogene) and SKI (SKI proto-oncogene).
FB Description
Sno oncogene (Snoo) encodes a protein that belongs to the highly conserved Sno/Ski family of Smad binding proteins. It specifically binds the product of Med and switches its affinity from the products of Mad to Smox, resulting in antagonism of the product of dpp and facilitation of Activin signaling. Snoo overexpression antagonizes both pathways.