Gene

PolA1

Species
Drosophila melanogaster
Symbol
PolA1
Name
DNA polymerase alpha subunit 1
Synonyms
  • 180 kDa subunit
  • 180 kDa subunit of DNA polymerase alpha
Biotype
protein coding gene
Automated Description
Enables 3'-5'-DNA exonuclease activity and DNA-directed DNA polymerase activity. Involved in DNA replication proofreading. Located in nucleus. Part of alpha DNA polymerase:primase complex. Is expressed in follicle cell; nurse cell; organism; and ovary. Human ortholog(s) of this gene implicated in Van Esch-O'Driscoll syndrome and X-linked reticulate pigmentary disorder. Orthologous to human POLA1 (DNA polymerase alpha 1, catalytic subunit).
FB Description
DNA polymerase alpha subunit 1 (PolA1) encodes the catalytic subunit of DNA polymerase alpha, responsible for initial synthesis on the leading strand and on each Okazaki fragment of the lagging strand.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45861
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
21.6670M21.6675M21.6680M21.6685M21.6690M21.6695M21.6700M21.6705M21.6710M21.6715M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions