Version: 8.0.0
Date: Tue Jan 28 2025
PMCA
Drosophila melanogasterFB:FBgn0259214
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

PMCA

Species
Drosophila melanogaster
Symbol
PMCA
Name
plasma membrane calcium ATPase
Synonyms
  • BEST:CK
  • BEST:CK01140
Biotype
protein coding gene
Automated Description
Predicted to enable P-type calcium transporter activity. Involved in intracellular calcium ion homeostasis. Located in plasma membrane. Is expressed in several structures, including adult head; adult heart; adult mushroom body; brain; and ellipsoid body. Human ortholog(s) of this gene implicated in X-linked spinocerebellar ataxia 1; autosomal dominant intellectual developmental disorder; autosomal dominant nonsyndromic deafness 82; and autosomal recessive nonsyndromic deafness 12. Orthologous to several human genes including ATP2B4 (ATPase plasma membrane Ca2+ transporting 4).
FB Description
plasma membrane calcium ATPase (PMCA) encodes a P-type ion pump found in the plasma membrane. It functions as a low-capacity, high-affinity Ca[2+]-extrusion mechanism, which is required for maintaining resting Ca[2+] levels in all cells. In the larval neuromuscular junction it plays an important role in restoring resting Ca[2+] levels after pre- or post-synaptic Ca[2+] influx.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24093
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          PMCA molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
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            Genetic Interactions

            PMCA role
            PMCA genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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