Version: 8.0.0
Date: Tue Jan 28 2025
out
Drosophila melanogasterFB:FBgn0259834
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

out

Species
Drosophila melanogaster
Symbol
out
Name
outsiders
Synonyms
  • BcDNA:LD28120
  • CG8062
Biotype
protein coding gene
Automated Description
Predicted to enable monocarboxylic acid transmembrane transporter activity. Involved in germ cell development. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; embryonic hypopharynx; embryonic/larval midgut interstitial cell; gnathal primordium; and somatic trunk mesoderm derivative. Human ortholog(s) of this gene implicated in cataract 47. Orthologous to human SLC16A12 (solute carrier family 16 member 12); SLC16A3 (solute carrier family 16 member 3); and SLC16A5 (solute carrier family 16 member 5).
FB Description
outsiders (out) encodes a monocarboxylate transporter involved in programmed cell death of primordial germ cell/pole cells.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11360
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
CG14196166661466 of 8☑ ☑☐☑☐☑☑☑ 
CG8051265556385 of 8☑ ☐☐☑☐☑☑☑ 
CG8034369144262 of 8☐ ☐☐☐☐☑☑☐ 
CG8468472037224 of 8☑ ☐☐☐☐☑☑☑ 
Sln568940204 of 8☑ ☐☐☐☐☑☑☑ 
chk678336193 of 8☐ ☐☐☐☐☑☑☑ 
CG13907774236194 of 8☑ ☐☐☐☐☑☑☑ 
Mct1866938224 of 8☑ ☐☐☐☐☑☑☑ 
hrm967838223 of 8☐ ☐☐☐☐☑☑☑ 
CG80281062938223 of 8☐ ☐☐☐☐☑☑☑ 
CG83891161537233 of 8☐ ☐☐☑☐☑☑☐ 
Targ1262435213 of 8☑ ☐☐☐☐☑☑☐ 
kar1324043262 of 8☐ ☐☐☐☐☑☑☐ 
CG100191423944232 of 8☐ ☐☐☐☐☑☑☐ 

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
fertile
germline cell
lethal - all die before end of pupal stage | recessive
lethal | recessive
primordial germ cell
some die during pupal stage | recessive
viable
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
No records match query. Try removing filters.
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    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    No records match query. Try removing filters.
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      Download all Alleles/Variants for all genes of the species

      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
      No records match query. Try removing filters.
      Showing 0 - 0 of 0 rows
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        Models

        No data available

        Sequence Feature Viewer

        Genome location
        Assembly version
        R6
        Viewer Help
        Data currently unavailable; sequence viewer under construction

        Sequence Details

        Loading...

        Expression

        Primary Sources
        Other Sources
        all annotationsall anatomical structuresalimentary part of gastrointestinal systemchemosensory systemcirculatory systemendocrine systemexocrine systemhemolymphoid systemhepatobiliary systemintegumental systemmechanosensory systemmusculoskeletal systemnervous systemrenal systemreproductive systemrespiratory systemsensory systemvestibulo-auditory systemvisual systemendodermectodermmesodermmesenchymeadipose tissueappendageentire extraembryonic componentimaginal precursorpharyngeal archotherall stagesembryo stagepost embryonic, pre-adultpost-juvenile adult stageall cellular componentsextracellular regionplasma membranesynapsecell junctioncell projectioncytoplasmic vesicleendosomevacuolegolgi apparatusendoplasmic reticulumcytosolmitochondrionnucleuschromosomecytoskeletonprotein-containing complexother locations
        out (Dme)
        Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

        Molecular Interactions

        7 interactor genes based on 7 annotations
        out molecule type
        Interactor gene
        Interactor species
        Interactor molecule type
        Detection methods
        Source
        Reference
        protein
        		CG7173Drosophila melanogaster
        protein
        • two hybrid
        		PMID:14605208
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        Genetic Interactions

        out role
        out genetic perturbation
        Interactor gene
        Interactor species
        Interactor role
        Interactor genetic perturbation
        Interaction type
        Phenotype or trait
        Source
        Reference
        suppressor gene
        		bskDrosophila melanogaster
        suppressed gene
        genetic suppression
          		PMID:28965825
          suppressor gene
          		MarfDrosophila melanogaster
          suppressed gene
          genetic suppression
            		PMID:28965825
            suppressor gene
            		ND-42Drosophila melanogaster
            suppressed gene
            genetic suppression
              		PMID:28965825
              suppressed gene
              		p53Drosophila melanogaster
              suppressor gene
              genetic suppression
                		PMID:18057102
                suppressor gene
                		sicilyDrosophila melanogaster
                suppressed gene
                genetic suppression
                  		PMID:28965825
                  suppressor gene
                  		SREBPDrosophila melanogaster
                  suppressed gene
                  genetic suppression
                    		PMID:28965825
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