Gene

p120ctn

Species
Drosophila melanogaster
Symbol
p120ctn
Name
p120 catenin
Synonyms
  • Adherens junction protein p120
  • Adherens-junction-protein-p120
Biotype
protein coding gene
Automated Description
Predicted to enable cadherin binding activity. Involved in several processes, including adherens junction maintenance; compound eye morphogenesis; and dendritic spine morphogenesis. Located in adherens junction; centrosome; and cytoplasm. Is expressed in several structures, including epithelium; follicle cell; ganglia; gut section; and presumptive embryonic/larval system. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in several diseases, including DiGeorge syndrome; anxiety disorder; arrhythmogenic right ventricular cardiomyopathy (multiple); blepharocheilodontic syndrome 2; and major depressive disorder. Orthologous to several human genes including PKP4 (plakophilin 4).
FB Description
p120 catenin (p120ctn) encodes an important modulator of cell adhesion. It binds to and stabilizes classic cadherin cell adhesion receptors at the cell surface. Unlike its mammalian homologs, it is non-essential but becomes essential if the levels of the product of shg are reduced.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10372
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
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4.596M4.598M4.600M4.602M4.604M4.606M4.608M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions