Version: 8.0.0
Date: Tue Jan 28 2025
stj
Drosophila melanogasterFB:FBgn0261041
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

stj

Species
Drosophila melanogaster
Symbol
stj
Name
straightjacket
Synonyms
  • alpha[[2]]delta
  • alpha[[2]]delta-3
Biotype
protein coding gene
Automated Description
Predicted to enable voltage-gated calcium channel activity. Involved in several processes, including bulk synaptic vesicle endocytosis; detection of temperature stimulus involved in sensory perception of pain; and negative regulation of synaptic assembly at neuromuscular junction. Located in presynaptic active zone. Is expressed in several structures, including adult brain; adult head; adult optic lobe; embryonic/larval salivary gland; and ganglia. Used to study heart conduction disease. Orthologous to human CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3).
FB Description
straightjacket (stj) encodes a voltage-gated calcium channel subunit involved in neuromuscular junction development and autophagosome maturation.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10166
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
            Viewer Help
            13.806M13.808M13.810M13.812M13.814M13.816M13.818M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            stj molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              stj role
              stj genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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