Gene

mgl

Species
Drosophila melanogaster
Symbol
mgl
Name
Megalin
Synonyms
  • anon-WO0140519.108
  • CG12139
Biotype
protein coding gene
Automated Description
Predicted to enable hormone binding activity. Involved in chitin-based cuticle development; regulation of adult chitin-containing cuticle pigmentation; and regulation of endocytosis. Located in apical plasma membrane. Is expressed in several structures, including Malpighian tubule primordium; anterior-posterior subdivision of organism; epithelium; extraembryonic structure; and gut section. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in Donnai-Barrow syndrome and autoimmune thyroiditis. Orthologous to human LRP2 (LDL receptor related protein 2).
FB Description
Megalin (mgl) encodes a protein involved in cuticle development and endocytosis regulation.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22722
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
9.36M9.38M9.40M9.42M9.44M9.46M9.48M9.50M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions