Gene

hkb

Species
Drosophila melanogaster
Symbol
hkb
Name
huckebein
Synonyms
  • 5953
  • anon-82B3
Biotype
protein coding gene
Automated Description
Enables sequence-specific DNA binding activity and transcription corepressor binding activity. Involved in several processes, including germ cell migration; negative regulation of transcription by RNA polymerase II; and nervous system development. Located in nucleus. Is expressed in several structures, including CNS glial cell; anlage in statu nascendi; embryonic procephalic segment; head epidermis primordium; and neuroblasts. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1K and congenital dyserythropoietic anemia type IVa. Orthologous to several human genes including KLF1 (KLF transcription factor 1); KLF14 (KLF transcription factor 14); and KLF16 (KLF transcription factor 16).
FB Description
huckebein (hkb) is expressed in patches within the embryonic neuroectoderm and a subset of neuroblasts and their progeny, where it is required for proper neuronal specification and axon targeting. It is a terminal gap gene mediating the maternal terminal information at the posterior end of the blastoderm embryo.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23235
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
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      Alleles and Variants

      Allele/Variant Symbol
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      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            4.3452M4.3454M4.3456M4.3458M4.3460M4.3462M4.3464M4.3466M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            hkb molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              hkb role
              hkb genetic perturbation
              Interactor gene
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