Gene

wb

Species
Drosophila melanogaster
Symbol
wb
Name
wing blister
Synonyms
  • A1
  • alpha laminin
Biotype
protein coding gene
Automated Description
Predicted to be an extracellular matrix structural constituent. Involved in digestive tract mesoderm development; epithelial structure maintenance; and gonad development. Located in basement membrane. Is expressed in several structures, including alary cell; border follicle cell; direct flight muscle precursor cell; female germline cell; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy; congenital merosin-deficient muscular dystrophy 1A; muscular dystrophy; and myopia. Orthologous to several human genes including LAMA1 (laminin subunit alpha 1).
FB Description
wing blister (wb) encodes one of 2 laminin alpha chains which assembles into a Laminin molecule. Laminin is an extracellular matrix component that interacts with integrins and mediates cell adhesion, guidance, signalling and basement membrane integrity.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10574
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
14.27M14.28M14.29M14.30M14.31M14.32M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions