Predicted to be an extracellular matrix structural constituent. Involved in digestive tract mesoderm development; epithelial structure maintenance; and gonad development. Located in basement membrane. Is expressed in several structures, including alary cell; border follicle cell; direct flight muscle precursor cell; female germline cell; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy; congenital merosin-deficient muscular dystrophy 1A; muscular dystrophy; and myopia. Orthologous to several human genes including LAMA1 (laminin subunit alpha 1).
FB Description
wing blister (wb) encodes one of 2 laminin alpha chains which assembles into a Laminin molecule. Laminin is an extracellular matrix component that interacts with integrins and mediates cell adhesion, guidance, signalling and basement membrane integrity.