Version: 8.0.0Date: Tue Jan 28 2025
Gene
kug
- Species
- Drosophila melanogaster
- Symbol
- kug
- Name
- kugelei
- Synonyms
- Cad76E
- CG7749
- Biotype
- protein coding gene
- Automated Description
- Enables cell adhesion molecule binding activity. Involved in several processes, including digestive tract morphogenesis; establishment of planar polarity of follicular epithelium; and oogenesis. Located in several cellular components, including basal plasma membrane; cell trailing edge; and focal adhesion. Is expressed in floor cell; main body follicle cell; nurse cell; roof cell; and spermatozoon. Human ortholog(s) of this gene implicated in carcinoma (multiple); colorectal cancer; and spinocerebellar ataxia 45. Orthologous to several human genes including FAT1 (FAT atypical cadherin 1) and FAT2 (FAT atypical cadherin 2).
- FB Description
- kugelei (kug) (also known as Fat2 or Fat-like) encodes a member of the cadherin superfamily of transmembrane proteins, which mediate cell-cell adhesion and/or cell-cell communication. It is related to the product of ft and its roles include control of planar cell polarity, collective cell migration and morphogenesis.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR24026
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
Phenotype Term | Annotation details | References |
|---|---|---|
| No records match query. Try removing filters. | ||
Showing 0 - 0 of 0 rows
per page
Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
|---|---|---|---|---|---|---|---|
| No records match query. Try removing filters. | |||||||
Showing 0 - 0 of 0 rows
per page
Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
|---|---|---|---|---|---|---|---|
| No records match query. Try removing filters. | |||||||
Showing 0 - 0 of 0 rows
per page
Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
|---|---|---|---|---|---|
| No records match query. Try removing filters. | |||||
Showing 0 - 0 of 0 rows
per page
Sequence Feature Viewer
- Genome location
- Chr3L:20005301...20024607 + (19.31 kb)
- Assembly version
- R6
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.