Version: 8.0.0
Date: Tue Jan 28 2025
5-HT2B
Drosophila melanogasterFB:FBgn0261929
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

5-HT2B

Species
Drosophila melanogaster
Symbol
5-HT2B
Name
5-hydroxytryptamine (serotonin) receptor 2B
Synonyms
  • 5-HT-2b
  • 5-HT[[2B]]
Biotype
protein coding gene
Automated Description
Enables G protein-coupled serotonin receptor activity. Involved in serotonin receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in dendrite and plasma membrane. Is expressed in adult head and hemocyte. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcoholic psychosis; cocaine dependence; nicotine dependence; and steatotic liver disease (multiple). Orthologous to several human genes including HTR2A (5-hydroxytryptamine receptor 2A) and HTR2C (5-hydroxytryptamine receptor 2C).
FB Description
5-hydroxytryptamine (serotonin) receptor 2B (5-HT2B) encodes a 5-hydroxytryptamine (serotonin) GPCR that belongs to the Class A GPCR family. They bind and transmit the signal from the neurotransmitter 5-HT (serotonin). The family can be subdivided into several subclasses based on pharmacology, signal transduction and structure. There are 5 genes encoding serotonin receptors in the Drosophila melanogaster genome: 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT7.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24247
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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      Transgenic Alleles

      Species
      (carrying the transgene)
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          5-HT2B molecule type
          Interactor gene
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            Genetic Interactions

            5-HT2B role
            5-HT2B genetic perturbation
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