Enables G protein-coupled serotonin receptor activity. Involved in serotonin receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in dendrite and plasma membrane. Is expressed in adult head and hemocyte. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcoholic psychosis; cocaine dependence; nicotine dependence; and steatotic liver disease (multiple). Orthologous to several human genes including HTR2A (5-hydroxytryptamine receptor 2A) and HTR2C (5-hydroxytryptamine receptor 2C).
FB Description
5-hydroxytryptamine (serotonin) receptor 2B (5-HT2B) encodes a 5-hydroxytryptamine (serotonin) GPCR that belongs to the Class A GPCR family. They bind and transmit the signal from the neurotransmitter 5-HT (serotonin). The family can be subdivided into several subclasses based on pharmacology, signal transduction and structure. There are 5 genes encoding serotonin receptors in the Drosophila melanogaster genome: 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT7.