Involved in cytoskeletal matrix organization at active zone; neuromuscular synaptic transmission; and presynaptic active zone organization. Located in cytoskeleton of presynaptic active zone. Is active in neuromuscular junction and presynaptic active zone cytoplasmic component. Is expressed in adult head and embryonic/larval neuromuscular junction. Human ortholog(s) of this gene implicated in dystonia 22, adult-onset and dystonia 22, juvenile-onset. Orthologous to several human genes including RIMBP2 (RIMS binding protein 2).
FB Description
RIM-binding protein (Rbp) encodes an active zone protein involved in neuromuscular synaptic transmission and presynaptic active zone organization.