Gene

S6kII

Species
Drosophila melanogaster
Symbol
S6kII
Name
Ribosomal protein S6 kinase II
Synonyms
  • CG17596
  • D-RSK
Biotype
protein coding gene
Automated Description
Enables mitogen-activated protein kinase binding activity and ribosomal protein S6 kinase activity. Involved in several processes, including learning; negative regulation of cell differentiation; and negative regulation of signal transduction. Located in several cellular components, including neuromuscular junction; perikaryon; and presynapse. Is expressed in adult head. Used to study Coffin-Lowry syndrome. Human ortholog(s) of this gene implicated in Coffin-Lowry syndrome; intellectual disability; and non-syndromic X-linked intellectual disability 19. Orthologous to several human genes including RPS6KA1 (ribosomal protein S6 kinase A1); RPS6KA2 (ribosomal protein S6 kinase A2); and RPS6KA3 (ribosomal protein S6 kinase A3).
FB Description
Ribosomal protein S6 kinase II (S6kII) encodes a protein that functions as a downstream effector and regulator of the MAP kinase pathway. It is involved in MAP kinase regulated developmental processes, organization of the neuromuscular junction and adult behavior including circadian rhythm and learning.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24351
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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      Transgenic Alleles

      Species
      (carrying the transgene)
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          S6kII molecule type
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            Genetic Interactions

            S6kII role
            S6kII genetic perturbation
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