Gene

mib1

Species
Drosophila melanogaster
Symbol
mib1
Name
mind bomb 1
Synonyms
  • CG5841
  • D-mib
Biotype
protein coding gene
Automated Description
Enables ubiquitin protein ligase activity. Involved in several processes, including lateral inhibition; positive regulation of Notch signaling pathway; and protein polyubiquitination. Located in apical cortex. Human ortholog(s) of this gene implicated in left ventricular noncompaction. Orthologous to human MIB1 (MIB E3 ubiquitin protein ligase 1).
FB Description
mind bomb 1 (mib1) encodes an E3 ubiquitin ligase that regulates Notch signaling by influencing the endocytosis of the products of Delta and Ser.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24202
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensMIB19 of 9YesYes   
Mus musculusMib19 of 9YesYes   
Rattus norvegicusMib19 of 9YesYes   
Xenopus tropicalismib19 of 9YesYes   
Danio reriomib110 of 10YesYes  
Caenorhabditis elegansmib-13 of 9YesNo   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
mib21118848336 of 8  
Ank286437222 of 8  
nompC348042252 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
eye
eye disc
eye | female | germline clone
eye | pharate adult stage
leg
leg | female | germline clone
leg | pharate adult stage
lethal - all die before end of pupal stage
lethal - all die before end of pupal stage | recessive
lethal | first instar larval stage
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
R6
Viewer Help
16.0070M16.0075M16.0080M16.0085M16.0090M16.0095M16.0100M16.0105M16.0110M16.0115M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
mib16
  • l(3)72Db[6]
  • l(3)72Db6
allele
mib18
  • l(3)72Db[8]
  • l(3)72Db8
allele
mib12
  • l(3)72Db[2]
  • l(3)72Db2
allele
mib172Db-3
  • l(3)72Db[3]
  • l(3)72Db3
allele
mib172Db-4
  • l(3)72Db[4]
  • l(3)72Db4
allele
mib1CR70264-KO-kG4
  • mib1[CR70264-KO-kG4]
allele
mib113
  • l(3)72Db[13]
  • l(3)72Db13
allele
mib114
  • l(3)72Db[14]
  • l(3)72Db14
allele
mib11
  • l(3)72Db[1]
  • l(3)72Db1
allele
mib116
  • l(3)72Db[16]
  • l(3)72Db16
allele
Showing 1 - 10 of 174 rows
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Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Drosophila melanogastermib1C.UAS.Tag:polyHis,Tag:MYC
  • UAS
Drosophila melanogastermib1C1205S.UAS.YFP
  • UAS
Drosophila melanogastermib1C1205S.UAS
  • UASt
Drosophila melanogastermib1GD11786
  • UASt
Drosophila melanogastermib1JF02629
  • UAS
Drosophila melanogastermib1N.UAS.Tag:polyHis,Tag:MYC
  • UAS
Drosophila melanogastermib1RNAi.UAS
  • UAS
Drosophila melanogastermib1TKO.GS04537
Drosophila melanogastermib1UAS.Tag:polyHis,Tag:MYC
  • UAS
Drosophila melanogastermib1UAS.YFP
  • UAS
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Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
16.0070M16.0075M16.0080M16.0085M16.0090M16.0095M16.0100M16.0105M16.0110M16.0115Mmib1-RA (mib1)mib1-RB (mib1)mRpS31-RA (mRpS31)

Sequence Details

Transcript: Mode:

Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

7 interactor genes based on 16 annotations
mib1 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
DeltaDrosophila melanogaster
protein
  • anti tag coimmunoprecipitation
PMID:15829515
protein
DeltaDrosophila melanogaster
protein
  • anti tag coimmunoprecipitation
PMID:15829515
protein
DeltaDrosophila melanogaster
protein
  • anti tag coimmunoprecipitation
PMID:22162135
protein
DeltaDrosophila melanogaster
protein
  • enzymatic study
PMID:22162135
protein
NDrosophila melanogaster
protein
  • two hybrid
PMID:15710747
protein
SerDrosophila melanogaster
protein
  • anti tag coimmunoprecipitation
PMID:15829515
protein
STUB1Drosophila melanogaster
protein
  • two hybrid
PMID:14605208
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Genetic Interactions

mib1 role
mib1 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
enhancer gene
DeltaDrosophila melanogaster
enhanced gene
genetic enhancement
    PMID:16093323
    suppressed gene
    NDrosophila melanogaster
    suppressor gene
    genetic suppression
      PMID:15760269
      suppressed gene
      neurDrosophila melanogaster
      suppressor gene
      genetic suppression
        PMID:15760269
        suppressed gene
        neurDrosophila melanogaster
        suppressor gene
        genetic suppression
          PMID:15829515
          enhancer gene
          neurDrosophila melanogaster
          enhanced gene
          genetic enhancement
            PMID:16093323
            suppressor gene
            neurDrosophila melanogaster
            suppressed gene
            genetic suppression
              PMID:15829515
              suppressor gene
              SerDrosophila melanogaster
              suppressed gene
              genetic suppression
                PMID:15829515
                suppressed gene
                α4GT1Drosophila melanogaster
                suppressor gene
                genetic suppression
                  PMID:20176925
                  suppressed gene
                  α4GT2Drosophila melanogaster
                  suppressor gene
                  genetic suppression
                    PMID:20176925
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