Gene

Hsc20

Species
Drosophila melanogaster
Symbol
Hsc20
Name
Heat shock protein cognate 20
Synonyms
  • CG34246
  • heat shock protein cognate 20
Biotype
protein coding gene
Automated Description
Predicted to enable ATPase activator activity and protein-folding chaperone binding activity. Involved in iron-sulfur cluster assembly. Is active in mitochondrion. Human ortholog(s) of this gene implicated in sideroblastic anemia. Orthologous to human HSCB (HscB mitochondrial iron-sulfur cluster cochaperone).
FB Description
Heat shock protein cognate 20 (Hsc20) encodes a mitochondrial chaperone that facilitates iron sulfur cluster assembly or transfer from the product of IscU to other scaffold proteins. Hsc20 is required for larval growth and cellular iron sensing.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14021
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
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16.2332M16.2333M16.2334M16.2335M16.2336M16.2337M16.2338M16.2339M16.2340M16.2341M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions