Version: 8.0.0
Date: Tue Jan 28 2025
BubR1
Drosophila melanogasterFB:FBgn0263855
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

BubR1

Species
Drosophila melanogaster
Symbol
BubR1
Name
Bub1-related kinase
Synonyms
  • 31/13
  • BcDNA:LD23835
Biotype
protein coding gene
Automated Description
Predicted to enable protein kinase activity. Involved in several processes, including chromosome organization; heterochromatin formation; and regulation of mitotic cell cycle phase transition. Located in cytoplasm and kinetochore. Is expressed in central brain primordium; larval ventral nerve cord; organism; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in colorectal cancer and primary autosomal recessive microcephaly. Orthologous to human BUB1 (BUB1 mitotic checkpoint serine/threonine kinase).
FB Description
Bub1-related kinase (BubR1) encodes a motif-rich protein with a C-terminal serine-threonine kinase domain. During prometaphase and metaphase, it plays important roles in spindle assembly checkpoint signalling, stabilization of kinetochore-microtuble attachments and chromosome alignment. It is also essential to maintain sister-chromatid cohesion during meiotic progression and for normal maintenance of Synaptonemal Complex in females.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14030
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
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      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
            Viewer Help
            5.9695M5.9700M5.9705M5.9710M5.9715M5.9720M5.9725M5.9730M5.9735M5.9740M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            BubR1 molecule type
            Interactor gene
            Interactor species
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              Genetic Interactions

              BubR1 role
              BubR1 genetic perturbation
              Interactor gene
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