Gene

dally

Species
Drosophila melanogaster
Symbol
dally
Name
division abnormally delayed
Synonyms
  • anon-EST:Liang-1.63
  • CG4974
Biotype
protein coding gene
Automated Description
Involved in several processes, including imaginal disc-derived appendage morphogenesis; regionalization; and regulation of signal transduction. Located in apical plasma membrane; basolateral plasma membrane; and external side of plasma membrane. Is expressed in several structures, including adult brain; compartment boundary; cuboidal/columnar epithelium; imaginal disc; and somatic cell of ovariole. Human ortholog(s) of this gene implicated in Simpson-Golabi-Behmel syndrome type 1; hepatocellular carcinoma; and nephroblastoma. Orthologous to several human genes including GPC5 (glypican 5).
FB Description
division abnormally delayed (dally) encodes a core protein of heparan sulfate proteoglycans of the glypican family. It acts as a co-receptor for growth factors and morphogens, such as the products of dpp, wg, hh, upd1 and FGFs, affecting signaling and distribution of these ligands. The roles of the product of dally include wing development and germline stem cell maintenance.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10822
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            8.83M8.84M8.85M8.86M8.87M8.88M8.89M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            dally molecule type
            Interactor gene
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              Genetic Interactions

              dally role
              dally genetic perturbation
              Interactor gene
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              Interactor genetic perturbation
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