Version: 8.0.0
Date: Tue Jan 28 2025
nonC
Drosophila melanogasterFB:FBgn0263968
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

nonC

Species
Drosophila melanogaster
Symbol
nonC
Name
no-on-and-no-off transient C
Synonyms
  • anon-EST:Liang-1.24
  • anon-WO0170980.133
Biotype
protein coding gene
Automated Description
Predicted to enable protein serine/threonine kinase activity. Involved in several processes, including neuromuscular synaptic transmission; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; and synaptic vesicle transport. Predicted to be part of TOR complex. Predicted to be active in cytoplasm and nucleus. Is expressed in peripodial epithelium of eye disc. Orthologous to human SMG1 (SMG1 nonsense mediated mRNA decay associated PI3K related kinase).
FB Description
no-on-and-no-off transient C (nonC) encodes a phosphatidylinositol 3-kinase-related kinase. It functions in the nonsense-mediated mRNA decay (NMD) pathway by phosphorylation of the core NMD regulator encoded by Upf1.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11139
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            Data currently unavailable; sequence viewer under construction

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            nonC molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              nonC role
              nonC genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
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