Version: 8.0.0
Date: Tue Jan 28 2025
sli
Drosophila melanogasterFB:FBgn0264089
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

sli

Species
Drosophila melanogaster
Symbol
sli
Name
slit
Synonyms
  • CG33464
  • CG43758
Biotype
protein coding gene
Automated Description
Enables Roundabout binding activity and heparin binding activity. Involved in several processes, including heart development; neurogenesis; and regulation of cell migration. Located in axon; cell surface; and extracellular region. Part of Slit-Robo signaling complex. Is expressed in several structures, including central nervous system; ganglia; glial cell; larval multidendritic neurons; and tract. Orthologous to human SLIT1 (slit guidance ligand 1); SLIT2 (slit guidance ligand 2); and SLIT3 (slit guidance ligand 3).
FB Description
slit (sli) encodes a secreted glycoprotein that acts as a ligand for the Robo receptor family and co-receptors, including the products of Sdc and Dscam1. The product of sli functions as second messenger (via Abl) and receptor dependent, providing repellent (neural growth cone), attractive (trachea), and polarising (cardioblasts) cues for differentiating cells.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45836
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Download all Alleles/Variants for all genes of the species

        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            15.870M15.875M15.880M15.885M15.890M15.895M15.900M15.905M15.910M15.915M15.920M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            sli molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              sli role
              sli genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
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