Enables small GTPase binding activity. Involved in several processes, including glycophagy; larval midgut cell programmed cell death; and neuron remodeling. Part of phosphatidylinositol 3-kinase complex, class III, type I. Human ortholog(s) of this gene implicated in Machado-Joseph disease and breast cancer. Orthologous to several human genes including BECN1 (beclin 1).
FB Description
Autophagy-related 6 (Atg6) encodes a component of the Vps34 complex that is required for the formation of PI3P, and functions in vesicle trafficking including autophagy and endocytosis.