Version: 8.0.0
Date: Tue Jan 28 2025
Mhc
Drosophila melanogasterFB:FBgn0264695
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Mhc

Species
Drosophila melanogaster
Symbol
Mhc
Name
Myosin heavy chain
Synonyms
  • beta-myosin heavy chain
  • Bsh
Biotype
protein coding gene
Automated Description
Enables microfilament motor activity and protein homodimerization activity. A structural constituent of muscle. Involved in several processes, including actin cytoskeleton organization; adult somatic muscle development; and epithelial cell migration. Located in A band and polytene chromosome puff. Is expressed in several structures, including adult digestive system; anterior-posterior subdivision of organism; gut section; muscle cell; and muscle system. Used to study cardiomyopathy (multiple) and muscle tissue disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including cardiomyopathy (multiple); congenital heart disease (multiple); contractures, pterygia, and spondylocarpotarsal fusion syndrome (multiple); heart conduction disease (multiple); and muscle tissue disease (multiple). Orthologous to several human genes including MYH1 (myosin heavy chain 1); MYH13 (myosin heavy chain 13); and MYH15 (myosin heavy chain 15).
FB Description
Myosin heavy chain (Mhc) encodes the motor protein that provides the force for muscle contraction through its ATP-dependent interaction with actin filaments. It functions with essential and regulatory light chains.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45615
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Mhc molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            Mhc role
            Mhc genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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