Gene

Mhc

Species
Drosophila melanogaster
Symbol
Mhc
Name
Myosin heavy chain
Synonyms
  • beta-myosin heavy chain
  • Bsh
Biotype
protein coding gene
Automated Description
Enables microfilament motor activity and protein homodimerization activity. A structural constituent of muscle. Involved in several processes, including actin cytoskeleton organization; adult somatic muscle development; and epithelial cell migration. Located in A band and polytene chromosome puff. Is expressed in several structures, including adult digestive system; anterior-posterior subdivision of organism; gut section; muscle cell; and muscle system. Used to study cardiomyopathy (multiple) and muscle tissue disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including cardiomyopathy (multiple); congenital heart disease (multiple); contractures, pterygia, and spondylocarpotarsal fusion syndrome (multiple); heart conduction disease (multiple); and muscle tissue disease (multiple). Orthologous to several human genes including MYH1 (myosin heavy chain 1); MYH13 (myosin heavy chain 13); and MYH15 (myosin heavy chain 15).
FB Description
Myosin heavy chain (Mhc) encodes the motor protein that provides the force for muscle contraction through its ATP-dependent interaction with actin filaments. It functions with essential and regulatory light chains.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45615
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            16.768M16.770M16.772M16.774M16.776M16.778M16.780M16.782M16.784M16.786M16.788M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Mhc molecule type
            Interactor gene
            Interactor species
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              Genetic Interactions

              Mhc role
              Mhc genetic perturbation
              Interactor gene
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