Gene

RhoGEF3

Species
Drosophila melanogaster
Symbol
RhoGEF3
Name
Rho guanine nucleotide exchange factor 3
Synonyms
  • CG1225
  • CG13881
Biotype
protein coding gene
Automated Description
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in actin cytoskeleton organization; melanotic encapsulation of foreign target; and wound healing. Predicted to be active in cytosol. Is expressed in several structures, including anlage in statu nascendi; ganglia; gut section; head epidermis primordium; and organism subdivision. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 8. Orthologous to human ARHGEF9 (Cdc42 guanine nucleotide exchange factor 9) and SPATA13 (spermatogenesis associated 13).
FB Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45834
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
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      Alleles and Variants

      Allele/Variant Symbol
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      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            RhoGEF3 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
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              Genetic Interactions

              RhoGEF3 role
              RhoGEF3 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
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