Enables non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including dorsal closure, spreading of leading edge cells; imaginal disc morphogenesis; and regulation of signal transduction. Located in cytoplasm and plasma membrane. Is expressed in several structures, including adult head; epithelial furrow; ganglia; imaginal disc; and tract. Used to study colorectal cancer and intestinal cancer. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; colorectal cancer (multiple); ductal carcinoma in situ; thrombocytopenia; and type 2 diabetes mellitus. Orthologous to several human genes including FRK (fyn related Src family tyrosine kinase).
FB Description
Src oncogene at 42A (Src42A) encodes the none-receptor tyrosine kinase regulating cell proliferation, cell adhesion and morphogenetic processes including dorsal closure, tracheal tube size control and germ band elongation. It is regulated by both inhibitory and activating tyrosine phosphorylation.