Gene

Src42A

Species
Drosophila melanogaster
Symbol
Src42A
Name
Src oncogene at 42A
Synonyms
  • CG14471
  • CG44128
Biotype
protein coding gene
Automated Description
Enables non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including dorsal closure, spreading of leading edge cells; imaginal disc morphogenesis; and regulation of signal transduction. Located in cytoplasm and plasma membrane. Is expressed in several structures, including adult head; epithelial furrow; ganglia; imaginal disc; and tract. Used to study colorectal cancer and intestinal cancer. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; colorectal cancer (multiple); ductal carcinoma in situ; thrombocytopenia; and type 2 diabetes mellitus. Orthologous to several human genes including FRK (fyn related Src family tyrosine kinase).
FB Description
Src oncogene at 42A (Src42A) encodes the none-receptor tyrosine kinase regulating cell proliferation, cell adhesion and morphogenetic processes including dorsal closure, tracheal tube size control and germ band elongation. It is regulated by both inhibitory and activating tyrosine phosphorylation.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24418
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
5.985M5.990M5.995M6.000M6.005M6.010M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions